Análisis del material audiovisual Los Lex de la Editorial Difusión desde la perspectiva de las estrategias de aprendizaje del léxico

Treballs Finals del Màster de Formació de Professor d'Espanyol com a Llengua Estrangera del "Centro Universitario Internacional de Barcelona (UNIBA)" Adscrit a la Universitat de Barcelona. Curs: 2019-2021, Tutora: Lola Torres[spa] El presente trabajo propone un análisis descriptivo de los videos educativos Los Lex de la Editorial Difusión para los niveles A1, A2 y B1 desde la perspectiva de las estrategias de enseñanza del léxico. Para ello se han revisado aportaciones del enfoque léxico, las estrategias para el aprendizaje de lenguas, el uso de las imágenes y animaciones en la clase de Español como Lengua Extranjera. Para el análisis se ha diseñado e implementado una ficha de observación donde se incluye una serie de parámetros que son esenciales para facilitar el desarrollo del lexicón mental, como por ejemplo la muestra de distinto tipo de unidades léxicas, el léxico en sus variadas dimensiones, actividades para aprender y desarrollar estrategias y la cantidad de repeticiones. Del resultado del análisis se aprecia la inclusión de los principios conceptuales de la didáctica del léxico, el uso de diferentes estrategias como la deducción por el contexto, la necesidad de propiciar un diálogo sobre las variedades diatópicas del español e incorporar un léxico personal para que el aprendiente se vea reflejado a sí mismo y a su mundo.[eng] The present work proposes a descriptive analysis of educational videos Los Lex published by Editorial Difusión aimed at levels A1, A2, and B1 from a perspective of lexical teaching strategies. The contributions of the lexical approach, the strategies for language learning, the use of images and animations in the class of Spanish as a Foreign Language have been reviewed. For the analysis, an observation sheet was designed and implemented, and included a series of parameters that are essential to facilitate the development of mental lexicon, such as samples of different types of lexical units, the lexicon in its various dimensions, activities to learn and develop strategies, and the number of repetitions. The result of the analysis shows the inclusion of the conceptual principles of the lexical approach, the use of different strategies such as deduction by the context, the need to promote a dialogue about the diatopic varieties of Spanish and incorporate a personal lexicon so the learner can reflect themselves and their own world

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Paws, claws and traces: the presence of animals in the poetry of Adília Lopes

Esta pesquisa tem como objetivo olhar para a poesia de Adília Lopes, poetisa portuguesa contemporânea, sob o prisma da zooliteratura, analisando as quatro principais imagens de animais de sua poética gatos, cães, peixes e serpentes. A investigação das várias significações que eles podem adquirir nos poemas adilianos também possibilitará compreender a proposta de desierarquizar a relação com e entre os animais (seja através da relação afetiva, da empatia ou da compaixão). A poetisa problematiza o lugar que os animais ocupam no mundo cotidiano e propõe uma revalorização desses seres. Ela não exclui o diferente, mas o reconhece. Pensar sobre o lugar de importância que os animais escritos têm na obra adiliana tece novos olhares não só sobre essa poética, mas também sobre a relação que se faz, ao longo desses anos, entre os animais e os seres humanos.This research has with its aim to look at the poetry of Adilia Lopes, contemporary Portuguese poet, under the zoo literature perspective, analysing the four main images of animals in her poetry cats, dogs, fish and serpentes. The investigation of several meanings that they can acquire in the adilianos poems will also enable to understand the proposal of non-hierarchic relation with and among the animals (it can happen through the affective relationship, empathy or compassion). The poet discusses the place that the animals take in the everyday world and leads to a revaluation of them. She does not exclude the different, but recognizes it. When we think about the place of importance that the written animals have in the adiliana book, it creates new looks not only in this poetic, but also in the relation which has been made, throughout the years, between animals and human beings

K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma : Correlation with clinical presentation

Kaposi’s sarcoma-associated herpesvirus (KSHV) causes both AIDS-related Kaposi’s sarcoma (KS) and classic KS, but their clinical presentations are different, and respective mechanisms remain to be elucidated. The KSHV K1 gene is reportedly involved in tumorigenesis through the immunoreceptor tyrosine-based activation motif (ITAM). Since we found the sequence variations in the K1 gene of KSHV isolated from AIDS-related KS and classic KS, we hypothesized that the transformation activity of the K1 gene contributes to the different clinical presentations. To evaluate our hypothesis, we compared the transformation activities of the K1 gene between AIDS-related KS and classic KS. We also analyzed ITAM activities and the downstream AKT and NF-κB. We found that the transformation activity of AIDS-related K1 was greater than that of classic K1, and that AIDS-related K1 induced higher ITAM activity than classic K1, causing more potent Akt and NF-κB activities. K1 downregulation by siRNA in AIDS-related K1 expressing cells induced a loss of transformation properties and decreased both Akt and NF-κB activities, suggesting a correlation between the transformation activity of K1 and ITAM signaling. Our study indicates that the increased transformation activity of AIDS-related K1 is associated with its clinical aggressiveness, whereas the weak transformation activity of classic type K1 is associated with a mild clinical presentation and spontaneous regression. The mechanism of spontaneous regression of classic KS may provide new therapeutic strategy to cancer.博士(医学)琉球大

Evidence for an association between increased oxidative stress and derangement of FOXO1 signaling in tumorigenesis of a cellular angiofibroma with monoallelic 13q14 : a case report

Cellular angiofibroma (CAF) is a rare soft tissue tumor characterized by random arrangement of spindle tumor cells in the stroma with short collagen bundles and thick- and hyalinized small vessels. CAFs share histological characteristics with spindle cell lipomas and mammary type myofibroblastomas. Because these tumors harbor monoallelic 13q14, common genetic and molecular mechanism for tumorigenesis is presumed. In this study, we reported a case of CAF in a 69-year-old man with monoallelic 13q14. Immunohistochemical analysis revealed that FOXO1, which is located in chromosome 13q14, was not expressed in the tumor. We also detected oxidative stress markers and found p38 MAPK activation, which is often induced by cellular stressors such as reactive oxygen species (ROS). Because FOXO1 induces the expression of genes encoding enzymes that generate antioxidants, oxidative stress induced by loss of FOXO1 expression may be common among CAFs, spindle cell lipomas, and mammary type myofibroblastomas